As targeted proteins that move within the cell, the steroid receptors have become very useful probes for understanding the linked phenomena of protein folding and transport. From the study of steroid receptor‐associated proteins it has become clear over the past two years that these receptors are bound to a multiprotein complex containing at least two heat shock proteins, hsp90 and hsp56. Attachment of receptors to this complex in a cell‐free system appears to require the protein unfolding/folding activity of a third (...) heat shock protein, hsp70. Like the oncogenic tyrosine kinase pp60src, steroid receptors bind to this complex of chaperone proteins at the time of their translation. Binding of the receptor to the hsp90 component of the system occurs through the hormone binding domain and is under strict hormonal control. The hormone binding domain of the receptor acts as a transferable regulatory unit that confers both tight hormonal control and hsp90 binding onto chimaeric proteins. The model of folding and transport being developed for steroid receptors leads to some general suggestions regarding the folding and transport of targeted proteins in the cell. (shrink)

The people and the value of their experience, by N. T. Pratt.--From kingship to democracy, by J. P. Harland.--Democracy at Athens, by G. M. Harper.--Athens and the Delian League, by B. D. Meritt.--Socialism at Sparta, by P. R. Coleman-Norton.--Tyranny, by M. Mac Laren.--Federal unions, by C. A. Robinson.--Alexander and the world state, by O. W. Reinmuth.--The Antigonids, by J. V. A. Fine.--Ptolemaic Egypt: a planned economy, by S. L. Wallace.--The Seleucids: the theory of monarchy, by G. Downey.--The political status (...) of the independent cities of Asia Minor in the Hellenistic period, by D. Magie.--The ideal states of Plato and Aristotle, by W. J. Oates.--Epilogue, by A. C. Johnson.--Bibliography (p. 225-233).--Index, by H. V. M. Dennis, III. (shrink)

Imperative sentences like Dance! do not seem to represent the world. Recent modal analyses challenge this idea, but its intuitive and historical appeal remain strong. This paper presents three new challenges for a non-representational analysis, showing that the obstacles facing it are even steeper than previously appreciated. I will argue that the only way for the non-representationalist to meet these three challenges is to adopt a dynamic semantics. Such a dynamic semantics is proposed here: imperatives introduce preferences between alternatives. This (...) characterization of meaning focuses on what function a sentence serves in discourse, rather than what that sentence refers to (e.g., a state of the world). By representing the meaning of imperatives, connectives and declaratives in a common dynamic format, the challenges posed for non-representationalism are met. (shrink)

A uniform theory of conditionals is one which compositionally captures the behavior of both indicative and subjunctive conditionals without positing ambiguities. This paper raises new problems for the closest thing to a uniform analysis in the literature (Stalnaker, Philosophia, 5, 269–286 (1975)) and develops a new theory which solves them. I also show that this new analysis provides an improved treatment of three phenomena (the import-export equivalence, reverse Sobel-sequences and disjunctive antecedents). While these results concern central issues in the study (...) of conditionals, broader themes in the philosophy of language and formal semantics are also engaged here. This new analysis exploits a dynamic conception of meaning where the meaning of a symbol is its potential to change an agent’s mental state (or the state of a conversation) rather than being the symbol’s content (e.g. the proposition it expresses). The analysis of conditionals is also built on the idea that the contrast between subjunctive and indicative conditionals parallels a contrast between revising and consistently extending some body of information. (shrink)

This book provides a unique, cogent, engaging account of environmental determinism that has long been much needed in the classroom and beyond." -- Andrew Sluyter, Associate Professor, Louisiana State University, USA This book pulls together major critiques of contemporary attempts to explain nature-society relations in an environmentally deterministic way. After defining key terms, it reviews the history of environmental determinism's rise and fall within geography in the early twentieth century. It discusses the key reasons for the doctrine's rejection and presents (...) alternative, non-deterministic frameworks developed within geography for analyzing the roles played by the environment in human affairs. The authors examine the rise in recent decades of neo-deterministic approaches to such issues as the demarcation of regions, the causes of civilizational collapse in prehistory, today's globally uneven patterns of human well-being, and the consequences of human-induced climate change. In each case, the authors draw on the insights and approaches of geography, the academic discipline most conversant with the interactions of society and environment, to challenge the widespread acceptance that such approaches have won. The book will appeal to those working on human-environmental research, international development and global policy initiatives. William B. Meyer is Associate Professor of Geography at Colgate University, USA. He is the author of several previous books, including Human Impact on the Earth, Americans and Their Weather: A History, and The Progressive Environmental Prometheans. His research interests include urban geography, environmental history, and the history of environmental thought. Dylan M.T. Guss works in the technology investment sector. (shrink)

In this paper, I examine various popular notions concerning the ethics of investing. I first consider and reject the absolutist view that it is always wrong to invest in evil companies and the view that what makes investments in evil companies morally objectionable is the fact that by making such investments, investors are taking steps to benefit from the wrongdoing of others. I then defend the view that what makes certain investments morally objectionable is the fact that by making such (...) investments, investors enable others to do wrong. According to this view, when weighing the purchase of a certain company's stock, investors should ask themselves the following question: Would this sort of investment, if made by many people, enable others to do wrong? If the answer to this question is yes, and if an investor nevertheless makes the investment in question, he can justifiably be accused of moral wrongdoing. (shrink)

The rapid pace of technological development often outstrips the ability of legislators and regulators to establish proper guardrails on emerging technologies. A solution is for those who develop, deploy, and use these technologies to develop themselves as moral agents—i.e., as agents capable of steering the course of emerging technologies in a direction that will benefit humanity. However, there is a dearth of literature discussing how to foster moral agency in computer science courses, and little if any research on the effectiveness (...) of such courses in computer science. This paper addresses this gap by providing an overview of an undergraduate course on technology ethics. It then shares and discusses a subset of data collected from a mixed-methods study using a pre-post design that sought to examine the course’s effectiveness in developing students’ moral, intellectual, and civic virtues, as well as related dispositions. (shrink)

Modern Moral Problems addresses moral quandaries that can beguile and confuse faithful Catholics. Written in a question-and-answer format, the book covers questions regarding sexuality, medical ethics, business practices, civic responsibilities, and the sacramental life of the Church. The extraordinary assortment of issuesforming a single, organized collectionis a valuable reference for anyone seeking clear and concise answers to tough moral questions. Written in a conversational tone often spliced with humor, this work by a highly respected moral theologian will be read with (...) fascination for its clarity of argument and fundamental good sense. Originally published as a monthly question-and-answer column in a magazine for priests, these selections by Msgr. William B. Smith retain a striking current topicality. Msgr. Smith often tackled matters of controversy in the Catholic Church, ones which continue to draw conflicting opinions. Interesting, informative, and eminently practical, this book conveys an overall impression that sound thinking about morality is rooted in a tradition within the Catholic Church, even when the answers to particular moral questions cannot be found in catechisms or Vatican documents. Msgr. Smith offers a clear-headed approach to the quandaries of our time precisely because of his training in traditional moral principles and his fidelity to the Catholic magisterium. This book should be in the possession of all seminarians and priests, who are bound to confront moral matters that are not so easily decided at first glance. But lay people, too, will find here rich responses to the challenging and sometimes unresolved moral questions they encounter in their own lives. (shrink)

This paper proposes a semantics for free choice permission that explains both the non-classical behavior of modals and disjunction in sentences used to grant permission, and their classical behavior under negation. It also explains why permissions can expire when new information comes in and why free choice arises even when modals scope under disjunction. On the proposed approach, deontic modals update preference orderings, and connectives operate on these updates rather than propositions. The success of this approach stems from its capacity (...) to capture the difference between expressing the preferences that give rise to permissions and conveying propositions about those preferences. (shrink)

The ArgumentMany of the epistemological issues that occupied natural philosophers of the seventeenth century were expressed visually in title-page engravings. One of those issues concerned the relative status to be accorded to evidence of the senses, as compared to knowledge gained by faith or reason. In title-page illustrations, the various arguments were often waged by a series of light metaphors: the Light of Reason, the Light of Nature, and the Lights of Sense, Scripture, and Grace. When such illustrations are examined (...) with the authors' theological views in mind, it becomes apparent that in the first half of the seventeenth century, Catholic authors favored the Light of Reason as a source of truth, while Protestant authors favored the Light of Nature. Since by the end of the century it was widely accepted by scientists of all religious persuasions that certain knowledge must be grounded in sense evidence and the direct study of nature, one might argue that in this instance Protestantism was responsible for nurturing an important development of the Scientific Revolution. However, the skewed nature of the sample and the large number of counterexamples available mitigate against taking this offshoot of the Merton thesis too seriously. (shrink)

Abstract As there are food gluttons, so there are energy gluttons. One difference is that energy gluttons are typically oblivious to how much energy they consume and the source of that energy. Their energy gluttony is a side effect of insatiable desire for material goods, which themselves are often associated with social status. Nonetheless, steps taken to deal with energy gluttony parallel those taken with food gluttony. Typically these fall into three categories: educational, political, and technological. I will examine a (...) fourth, however, best characterized as philosophical. I will show how, by following the advice of the ancient Stoics and training ourselves to care less what others think of us, we can help overcome our desire for social status, resulting in a reduction in our desire for material things and a significant reduction in our personal energy bill. The pessimistic conclusion, however, is that most people are probably unwilling to undergo the self-analysis and self-transformation that this philosophical approach requires. (shrink)

Biodiversity and genetic resources have become the focal point of major national and international biological and political debates regarding control, ownership, access, and erosion of critical resources. While these issues are key to environmental sustainability and food security, biodiversity and genetic resources must be seen in the broader context of their inextricable relationship to cultural diversity and to humans' view of nature. Nature is assumed to be constituted socially through a wide variety of human processes described collectively as culture. Three (...) significant cultural factors, technology, science, and capitalism, are largely responsible for the secularization and homogenization of food and agriculture and the remaking of nature. These processes and forces may simultaneously and unwittingly create the problems of declines in biodiversity, cultural diversity, and food equity. Indeed, it may well be that the only way to conserve cultural biodiversity in the field is to conserve cultural diversity among peoples. This reunification of biodiversity and cultural diversity and food and agriculture will require new paradigms and institutional mechanisms that allow us to show our care for each other through our reverence for nature. (shrink)

First published in 1988, this volume was originally published, according to the authors, thanks to a 'conscious call'. They were 'fully persuaded that the honor of Christ and the very life of His church are alike endangered by the doubting spirit now brooding over the educational institutions of America.' The book contains chapters on the prominence of scepticism in schools; the theory of evolution and false theology; and the sacred scriptures.

No existing conditional semantics captures the dual role of 'if' in embedded interrogatives — 'X wonders if p' — and conditionals. This paper presses the importance and extent of this challenge, linking it to cross-linguistic patterns and other phenomena involving conditionals. Among these other phenomena are conditionals with multiple 'if'-clauses in the antecedent — 'if p and if q, then r' — and relevance conditionals — 'if you are hungry, there is food in the cupboard'. Both phenomena are shown to (...) be problematic for existing analyses. Surprisingly, the decomposition of conditionals needed to capture the link with interrogatives provides a new analysis that captures all three phenomena. The model-theoretic semantics offered here relies on a dynamic conception of meaning and compositionality, a feature discussed throughout. (shrink)

This article updates the author’s 1982 argument that lutetium and lawrencium, rather than lanthanum and actinium, should be assigned to the d-block as the heavier analogs of scandium and yttrium, whereas lanthanum and actinium should be considered as the first members of the f-block with irregular configurations. This update is embedded within a detailed analysis of Lavelle’s abortive 2008 attempt to discredit this suggestion.

In A Slap in the Face, William Irvine undertakes a wide-ranging investigation of insults, their history, the role they play in social relationships, and the science behind them.

Over the past two decades, the understanding of the roles of vitamin D has expanded to include many nonskeletal effects such as reduced risk of acute respiratory tract infections, autoimmune diseases, cancer, cardiovascular disease, diabetes mellitus, neurological diseases, and adverse pregnancy and birth outcomes. The role of vitamin D for optimal health is well known in Western developed countries but less so in Central Asian countries. This narrative review compares the status of vitamin D between Central Asian countries and Northern (...) European countries. The analysis also summarizes the evidence for the beneficial effects of vitamin D and recommendations for Central Asian countries. (shrink)

If forced to state Feuerbach’s philosophical genealogy, one would have to say that he was son of Hegel, father of Marx, and half-brother of Comte. In his own day he had many a celebratory and many a vilifier. His philosophy has received very little direct treatment in the English language. Feuerbach’s contribution was in his writings on religion and philosophy, each of them a manifesto to humanity, telling us that the desires of men can be satisfied here below. The object (...) of this book, first published in 1941, is twofold. It is its intention to pay humble tribute to a little understood philosopher whose stature grows with the years, and in so doing perhaps to provide a key to the question of religion and personal immortality for those who reject philosophical idealism and a personal God. (shrink)

As America's debate over federal funding of embryonic stem cell research continues to deepen, it is increasingly characterized as a conflict between the objectivity of secular science and the cultural variability of traditional religion. Yet science alone, by the very limitations of its naturalistic methodology and domain of knowledge, is unable to draw its own moral boundaries. Through a careful consideration of the relationship between scientific knowledge and our most fundamental assumptions concerning the moral value of developing life, we may (...) discern the terms of a possible resolution to our current conflict. In May 2005, the President's Council on Bioethics issued a report "Alternative Sources of Human Pluripotent Stem Cells," that discusses four proposals for a technological means of obtaining pluripotent stem cells without the destruction of human embryos. Drawing on the principles laid out in this report we discuss one of these proposals, Altered Nuclear Transfer, as a way forward that can sustain social consensus while opening avenues for scientific advance. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:St. John Henry Newman's Theory of Doctrinal Development and the Synodal Process:A Survey and Concrete ApplicationWilliam B. GoldinGood afternoon, Your Excellencies, Most Reverend bishops, and my brother priests. Firstly, please permit me to say that, while it is certainly an honor to have been invited to speak to you, for which I would like to express my gratitude to my own bishop and our host for this reunion, His (...) Excellency, Bishop Kevin W. Vann, it is also not a little bit daunting. To speak to such an erudite group of clerics, all of whom have a connection to our common alma mater and to the various celebrated universities in the Eternal City, brings back fond memories of my three years at the Casa Santa Maria. During that time, while I would occasionally have the opportunity to preach at Sunday Masses at the Casa, I was always keenly aware that I was not nearly as qualified to do so as many of my listeners. As such, I beg your pardon if I should fail to explain adequately any aspect of this lecture, and I would be grateful for any questions and/or corrections, theological or otherwise, that you may have afterwards.Let us begin with a prayer:In the Name of the Father, and of the Son, and of the Holy Spirit. Amen. [End Page 21]Come, Holy Spirit, fill the hearts of thy faithful, and enkindle in them the fire of thy love. Send forth thy Spirit and they shall be created, and thou shalt renew the face of the earth.Let us pray.O God, who didst inspire thy faithful by the light of thy Holy Spirit, grant that, in the same Spirit we may be truly wise and ever more rejoice in His holy consolation.Through Christ our Lord.Amen.Vergine Immacolata... Aiutateci.Introduction: The Synod on Synodality and Speculation on Doctrinal ChangeIn the late autumn of 2021, Bishop Vann appointed me and my colleague, Mrs. Katie Dawson, our diocesan director of parish faith formation, as the coordinators for the Synod on Synodality in the Diocese of Orange. In this role, we were tasked with bringing to fruition the diocesan phase of the synodal consultation of the faithful here in Orange County. Since last autumn, we have labored to carry out the bishop's synodal plan for this diocese, and I must say that I have been pleasantly surprised with the manner in which the consultation took place, and in its results, notwithstanding my initial reservations both as to the scope of this particular synod and as to the potential risks inherent in such a universal survey. As we all know from diocesan and parochial life, "listening sessions" have a tendency to become "shouting sessions"; and as a thoroughgoing introvert myself, such sessions do not exactly bring joy to my heart. Thankfully, though, my fears were not realized, and the actual experience of our synodal process was almost altogether pleasant.Perhaps surprisingly, one of the fruits of our consultation, which we heard from the majority of the faithful, is their clear desire for doctrinal clarity in their faith journeys. The majority of the People of God in Orange County whom we surveyed do not want to see any doctrinal changes emerge from this synod that could be critiqued for being in serious discontinuity with the [End Page 22] solemnly defined magisterial teaching of the past. Regularly, they expressed to us that, if our "journeying together" is to be authentic and credible, then the continuity of our doctrinal teaching is a matter of no small importance. Indeed, the ability of many to take the Church's faith seriously depends on whether the doctrinal content of that faith seems solid and unshakeable. If the content of our faith can shift substantially in ways that mirror modern shifts in secular thinking, then people can easily critique our faith as being blown about by the winds of change, with no certitude whatsoever. If something taught by the Catholic Church can be true today and false tomorrow, then why is the Catholic Church's message worth listening to at all? What we heard from the overwhelming majority of... (shrink)